Ionis Pharmaceuticals, Inc. (IONS)

Last Closing Price: 35.59 (2025-06-13)

Profile
Ticker
IONS
Security Name
Ionis Pharmaceuticals, Inc.
Exchange
NASDAQ
Sector
Healthcare
Industry
Biotechnology
Free Float
155,021,000
Market Capitalization
5,669,250,000
Average Volume (Last 20 Days)
1,367,470
Beta (Past 60 Months)
0.18
Percentage Held By Insiders (Latest Annual Proxy Report)
2.60
Percentage Held By Institutions (Latest 13F Reports)
93.86
Recent Price/Volume
Closing Price
35.59
Opening Price
35.13
High Price
35.67
Low Price
35.05
Volume
1,429,000
Previous Closing Price
35.62
Previous Opening Price
35.76
Previous High Price
36.16
Previous Low Price
35.30
Previous Volume
1,623,000
High/Low Price
52-Week High Price
52.34
26-Week High Price
38.90
13-Week High Price
37.60
4-Week High Price
37.60
2-Week High Price
37.60
1-Week High Price
37.60
52-Week Low Price
23.95
26-Week Low Price
23.95
13-Week Low Price
23.95
4-Week Low Price
32.00
2-Week Low Price
33.43
1-Week Low Price
35.05
High/Low Volume
52-Week High Volume
11,418,366
26-Week High Volume
4,063,354
13-Week High Volume
3,444,737
4-Week High Volume
2,858,000
2-Week High Volume
2,033,000
1-Week High Volume
2,033,000
52-Week Low Volume
502,727
26-Week Low Volume
502,727
13-Week Low Volume
693,266
4-Week Low Volume
811,293
2-Week Low Volume
835,000
1-Week Low Volume
1,429,000
Money Flow
Total Money Flow, Past 52 Weeks
14,642,000,977
Total Money Flow, Past 26 Weeks
6,605,708,995
Total Money Flow, Past 13 Weeks
3,226,641,458
Total Money Flow, Past 4 Weeks
958,459,591
Total Money Flow, Past 2 Weeks
511,424,685
Total Money Flow, Past Week
297,807,505
Total Money Flow, 1 Day
50,638,997
Total Volume
Total Volume, Past 52 Weeks
392,968,690
Total Volume, Past 26 Weeks
203,848,975
Total Volume, Past 13 Weeks
102,984,153
Total Volume, Past 4 Weeks
27,789,396
Total Volume, Past 2 Weeks
14,361,000
Total Volume, Past Week
8,224,000
Percent Change in Price
Percent Change in Price, Past 52 Weeks
-12.45
Percent Change in Price, Past 26 Weeks
-2.79
Percent Change in Price, Past 13 Weeks
7.98
Percent Change in Price, Past 4 Weeks
6.05
Percent Change in Price, Past 2 Weeks
6.21
Percent Change in Price, Past Week
0.85
Percent Change in Price, 1 Day
-0.08
New High/Low in Price
Reached New 52-Week High Price
False
Reached New 26-Week High Price
False
Reached New 13-Week High Price
False
Reached New 4-Week High Price
False
Reached New 2-Week High Price
False
Reached New 1-Week High Price
False
Reached New 52-Week Low Price
False
Reached New 26-Week Low Price
False
Reached New 13-Week Low Price
False
Reached New 4-Week Low Price
False
Reached New 2-Week Low Price
False
Reached New 1-Week Low Price
True
Consecutive Days/Weeks of Increasing/Decreasing Price
Consecutive Days of Increasing Price
0
Consecutive Weeks of Increasing Price
3
Consecutive Days of Decreasing Price
3
Consecutive Weeks of Decreasing Price
0
Consecutive Days/Weeks of Increasing/Decreasing Volume
Consecutive Days of Increasing Volume
0
Consecutive Weeks of Increasing Volume
1
Consecutive Days of Decreasing Volume
1
Consecutive Weeks of Decreasing Volume
0
New High/Low in Volume
Had New 52-Week High Volume
False
Had New 26-Week High Volume
False
Had New 13-Week High Volume
False
Had New 4-Week High Volume
False
Had New 2-Week High Volume
False
Had New 1-Week High Volume
False
Had New 52-Week Low Volume
False
Had New 26-Week Low Volume
False
Had New 13-Week Low Volume
False
Had New 4-Week Low Volume
False
Had New 2-Week Low Volume
False
Had New 1-Week Low Volume
True
Moving Averages
Simple Moving Average (5-Day)
36.20
Simple Moving Average (10-Day)
35.55
Simple Moving Average (20-Day)
34.50
Simple Moving Average (50-Day)
31.82
Simple Moving Average (100-Day)
32.08
Simple Moving Average (200-Day)
35.31
Previous Simple Moving Average (5-Day)
36.14
Previous Simple Moving Average (10-Day)
35.34
Previous Simple Moving Average (20-Day)
34.37
Previous Simple Moving Average (50-Day)
31.68
Previous Simple Moving Average (100-Day)
32.05
Previous Simple Moving Average (200-Day)
35.36
Technical Indicators
MACD (12, 26, 9)
1.08
MACD (12, 26, 9) Signal
1.03
Previous MACD (12, 26, 9)
1.13
Previous MACD (12, 26, 9) Signal
1.01
RSI (14-Day)
60.77
Previous RSI (14-Day)
61.02
Stochastic (14, 3, 3) %K
67.86
Stochastic (14, 3, 3) %D
76.32
Previous Stochastic (14, 3, 3) %K
75.30
Previous Stochastic (14, 3, 3) %D
83.41
Upper Bollinger Band (20, 2)
37.01
Lower Bollinger Band (20, 2)
32.00
Previous Upper Bollinger Band (20, 2)
36.91
Previous Lower Bollinger Band (20, 2)
31.84
Income Statement Financials
Quarterly Revenue (MRQ)
131,612,000
Quarterly Net Income (MRQ)
-146,938,000
Previous Quarterly Revenue (QoQ)
226,577,000
Previous Quarterly Revenue (YoY)
119,497,000
Previous Quarterly Net Income (QoQ)
-104,349,000
Previous Quarterly Net Income (YoY)
-142,803,000
Revenue (MRY)
705,138,000
Net Income (MRY)
-453,897,000
Previous Annual Revenue
787,647,000
Previous Net Income
-366,286,000
Cost of Goods Sold (MRY)
11,215,000
Gross Profit (MRY)
693,923,000
Operating Expenses (MRY)
1,180,219,000
Operating Income (MRY)
-475,081,000
Non-Operating Income/Expense (MRY)
15,013,000
Pre-Tax Income (MRY)
-460,068,000
Normalized Pre-Tax Income (MRY)
-457,167,000
Income after Taxes (MRY)
-453,897,000
Income from Continuous Operations (MRY)
-453,897,000
Consolidated Net Income/Loss (MRY)
-453,897,000
Normalized Income after Taxes (MRY)
-450,957,100
EBIT (MRY)
-475,081,000
EBITDA (MRY)
-484,134,000
Balance Sheet Financials
Current Assets (MRQ)
2,418,932,000
Property, Plant, and Equipment (MRQ)
102,925,000
Long-Term Assets (MRQ)
394,016,000
Total Assets (MRQ)
2,812,948,000
Current Liabilities (MRQ)
250,293,000
Long-Term Debt (MRQ)
1,250,718,000
Long-Term Liabilities (MRQ)
2,086,929,000
Total Liabilities (MRQ)
2,337,222,000
Common Equity (MRQ)
475,725,800
Tangible Shareholders Equity (MRQ)
475,726,100
Shareholders Equity (MRQ)
475,726,000
Common Shares Outstanding (MRQ)
159,041,000
Cash Flow Statement Financials
Cash Flow from Operating Activities (MRY)
-500,947,000
Cash Flow from Investing Activities (MRY)
-134,027,000
Cash Flow from Financial Activities (MRY)
478,058,000
Beginning Cash (MRY)
399,266,000
End Cash (MRY)
242,077,000
Increase/Decrease in Cash (MRY)
-157,189,000
Fundamental Ratios
PE Ratio (Current Year Earnings Estimate)
PE Ratio (Trailing 12 Months)
PEG Ratio (Long Term Growth Estimate)
Price to Sales Ratio (Trailing 12 Months)
7.90
Price to Book Ratio (Most Recent Quarterly Book Value per Share)
11.92
Price to Cash Ratio (Most Recent Annual Cash Flow per Share)
Pre-Tax Margin (Trailing 12 Months)
-64.65
Net Margin (Trailing 12 Months)
-63.65
Return on Equity (Trailing 12 Months)
-91.85
Return on Assets (Trailing 12 Months)
-15.77
Current Ratio (Most Recent Fiscal Quarter)
9.66
Quick Ratio (Most Recent Fiscal Quarter)
9.62
Debt to Common Equity (Most Recent Fiscal Quarter)
2.63
Inventory Turnover (Trailing 12 Months)
0.52
Book Value per Share (Most Recent Fiscal Quarter)
3.73
Earnings
Fiscal Period End, Next Quarterly Earnings Report
2025-06-30
Quarterly Earnings per Share Estimate
-0.58
Next Expected Quarterly Earnings Report Date
2025-08-07
Days Until Next Expected Quarterly Earnings Report
54
Fiscal Period End, Last Quarterly Earnings Report
2025-03-31
Last Quarterly Earnings per Share Estimate
-1.16
Last Quarterly Earnings per Share
-0.93
Last Quarterly Earnings Report Date
2025-04-30
Days Since Last Quarterly Earnings Report
45
Earnings per Share (Most Recent Fiscal Year)
-3.04
Diluted Earnings per Share (Trailing 12 Months)
-2.99
Dividends
Last Dividend Date
Last Dividend Amount
Days Since Last Dividend
Annual Dividend (Based on Last Quarter)
0.00
Dividend Yield (Based on Last Quarter)
0.00
Percent Growth in Revenue/Net Income
Percent Growth in Quarterly Revenue (QoQ)
-41.91
Percent Growth in Quarterly Revenue (YoY)
10.14
Percent Growth in Annual Revenue
-10.48
Percent Growth in Quarterly Net Income (QoQ)
-40.81
Percent Growth in Quarterly Net Income (YoY)
-2.90
Percent Growth in Annual Net Income
-23.92
New High/Low in Revenue/Net Income
New 5-Year High Annual Revenue
False
New 5-Year Low Annual Revenue
False
New 5-Year High Quarterly Revenue (QoQ)
False
New 5-Year Low Quarterly Revenue (QoQ)
False
New 5-Year High Quarterly Revenue (YoY)
False
New 5-Year Low Quarterly Revenue (YoY)
False
New 5-Year High Annual Net Income
False
New 5-Year Low Annual Net Income
True
New 5-Year High Quarterly Net Income (QoQ)
False
New 5-Year Low Quarterly Net Income (QoQ)
False
New 5-Year High Quarterly Net Income (YoY)
False
New 5-Year Low Quarterly Net Income (YoY)
True
Consecutive Quarters/Years of Increasing/Decreasing Revenue/Net Income
Consecutive Quarters of Increasing Revenue (QoQ)
0
Consecutive Quarters of Decreasing Revenue (QoQ)
1
Consecutive Quarters of Increasing Revenue (YoY)
1
Consecutive Quarters of Decreasing Revenue (YoY)
0
Consecutive Years of Increasing Revenue
0
Consecutive Years of Decreasing Revenue
1
Consecutive Quarters of Increasing Net Income (QoQ)
0
Consecutive Quarters of Decreasing Net Income (QoQ)
1
Consecutive Quarters of Increasing Net Income (YoY)
0
Consecutive Quarters of Decreasing Net Income (YoY)
2
Consecutive Years of Increasing Net Income
0
Consecutive Years of Decreasing Net Income
3
Splits
Last Split Date (if within past year)
Last Split Ratio (if within past year)
Days Since Last Split (if within past year)
Volatility Metrics
Historical Volatility (Close-to-Close) (10-Day)
0.2869
Historical Volatility (Close-to-Close) (20-Day)
0.2931
Historical Volatility (Close-to-Close) (30-Day)
0.2797
Historical Volatility (Close-to-Close) (60-Day)
0.3232
Historical Volatility (Close-to-Close) (90-Day)
0.4883
Historical Volatility (Close-to-Close) (120-Day)
0.4613
Historical Volatility (Close-to-Close) (150-Day)
0.4567
Historical Volatility (Close-to-Close) (180-Day)
0.4512
Historical Volatility (Parkinson) (10-Day)
0.2610
Historical Volatility (Parkinson) (20-Day)
0.3004
Historical Volatility (Parkinson) (30-Day)
0.2924
Historical Volatility (Parkinson) (60-Day)
0.3492
Historical Volatility (Parkinson) (90-Day)
0.4622
Historical Volatility (Parkinson) (120-Day)
0.4665
Historical Volatility (Parkinson) (150-Day)
0.4536
Historical Volatility (Parkinson) (180-Day)
0.4457
Implied Volatility (Calls) (10-Day)
0.6599
Implied Volatility (Calls) (20-Day)
0.5315
Implied Volatility (Calls) (30-Day)
0.4031
Implied Volatility (Calls) (60-Day)
0.3997
Implied Volatility (Calls) (90-Day)
0.4716
Implied Volatility (Calls) (120-Day)
0.4637
Implied Volatility (Calls) (150-Day)
0.4622
Implied Volatility (Calls) (180-Day)
0.4698
Implied Volatility (Puts) (10-Day)
0.6987
Implied Volatility (Puts) (20-Day)
0.5969
Implied Volatility (Puts) (30-Day)
0.4951
Implied Volatility (Puts) (60-Day)
0.4458
Implied Volatility (Puts) (90-Day)
0.4488
Implied Volatility (Puts) (120-Day)
0.4776
Implied Volatility (Puts) (150-Day)
0.4888
Implied Volatility (Puts) (180-Day)
0.4928
Implied Volatility (Mean) (10-Day)
0.6793
Implied Volatility (Mean) (20-Day)
0.5642
Implied Volatility (Mean) (30-Day)
0.4491
Implied Volatility (Mean) (60-Day)
0.4227
Implied Volatility (Mean) (90-Day)
0.4602
Implied Volatility (Mean) (120-Day)
0.4707
Implied Volatility (Mean) (150-Day)
0.4755
Implied Volatility (Mean) (180-Day)
0.4813
Put-Call Implied Volatility Ratio (10-Day)
1.0588
Put-Call Implied Volatility Ratio (20-Day)
1.1231
Put-Call Implied Volatility Ratio (30-Day)
1.2283
Put-Call Implied Volatility Ratio (60-Day)
1.1154
Put-Call Implied Volatility Ratio (90-Day)
0.9516
Put-Call Implied Volatility Ratio (120-Day)
1.0299
Put-Call Implied Volatility Ratio (150-Day)
1.0576
Put-Call Implied Volatility Ratio (180-Day)
1.0490
Implied Volatility Skew (10-Day)
0.2227
Implied Volatility Skew (20-Day)
0.2107
Implied Volatility Skew (30-Day)
0.1987
Implied Volatility Skew (60-Day)
0.1287
Implied Volatility Skew (90-Day)
0.0513
Implied Volatility Skew (120-Day)
0.0676
Implied Volatility Skew (150-Day)
0.0479
Implied Volatility Skew (180-Day)
0.0109
Option Statistics
Put-Call Ratio (Volume) (10-Day)
0.0000
Put-Call Ratio (Volume) (20-Day)
0.0000
Put-Call Ratio (Volume) (30-Day)
0.0000
Put-Call Ratio (Volume) (60-Day)
0.0000
Put-Call Ratio (Volume) (90-Day)
0.0000
Put-Call Ratio (Volume) (120-Day)
0.0000
Put-Call Ratio (Volume) (150-Day)
0.0000
Put-Call Ratio (Volume) (180-Day)
0.0000
Put-Call Ratio (Open Interest) (10-Day)
0.0535
Put-Call Ratio (Open Interest) (20-Day)
0.2109
Put-Call Ratio (Open Interest) (30-Day)
0.3684
Put-Call Ratio (Open Interest) (60-Day)
0.4769
Put-Call Ratio (Open Interest) (90-Day)
0.5126
Put-Call Ratio (Open Interest) (120-Day)
0.2492
Put-Call Ratio (Open Interest) (150-Day)
0.2137
Put-Call Ratio (Open Interest) (180-Day)
0.2623
Percentiles Within Industry of Price Performance
Percentile Within Industry, Percent Change in Price, Past 52 Weeks
66.06
Percentile Within Industry, Percent Change in Price, Past 26 Weeks
67.43
Percentile Within Industry, Percent Change in Price, Past 13 Weeks
67.43
Percentile Within Industry, Percent Change in Price, Past 4 Weeks
52.60
Percentile Within Industry, Percent Change in Price, Past 2 Weeks
58.72
Percentile Within Industry, Percent Change in Price, Past Week
73.24
Percentile Within Industry, Percent Change in Price, 1 Day
79.82
Percentiles Within Industry of Revenue/Net Income Growth
Percentile Within Industry, Percent Growth in Quarterly Revenue (QoQ)
20.74
Percentile Within Industry, Percent Growth in Quarterly Revenue (YoY)
44.14
Percentile Within Industry, Percent Growth in Annual Revenue
30.00
Percentile Within Industry, Percent Growth in Quarterly Net Income (QoQ)
17.62
Percentile Within Industry, Percent Growth in Quarterly Net Income (YoY)
50.97
Percentile Within Industry, Percent Growth in Annual Net Income
34.88
Percentiles Within Industry of Fundamental Ratios and Percentages
Percentile Within Industry, PE Ratio (Current Year Earnings Estimate)
Percentile Within Industry, PE Ratio (Trailing 12 Months)
Percentile Within Industry, PEG Ratio (Long Term Growth Estimate)
Percentile Within Industry, Price to Sales Ratio (Trailing 12 Months)
53.33
Percentile Within Industry, Price to Book Ratio (Most Recent Quarterly Book Value per Share)
90.29
Percentile Within Industry, Price to Cash Ratio (Most Recent Annual Cash Flow per Share)
Percentile Within Industry, Pre-Tax Margin (Trailing 12 Months)
70.84
Percentile Within Industry, Net Margin (Trailing 12 Months)
66.30
Percentile Within Industry, Return on Equity (Trailing 12 Months)
39.26
Percentile Within Industry, Return on Assets (Trailing 12 Months)
83.67
Percentile Within Industry, Current Ratio (Most Recent Fiscal Quarter)
75.43
Percentile Within Industry, Quick Ratio (Most Recent Fiscal Quarter)
75.47
Percentile Within Industry, Debt to Common Equity (Most Recent Fiscal Quarter)
96.08
Percentile Within Industry, Inventory Turnover (Trailing 12 Months)
19.50
Percentile Within Industry, Dividend Yield (Based on Last Quarter)
99.39
Percentile Within Industry, Percentage Held By Insiders (Latest Annual Proxy Report)
14.22
Percentile Within Industry, Percentage Held By Institutions (Latest 13F Reports)
89.04
Percentiles Within Sector of Price Performance
Percentile Within Sector, Percent Change in Price, Past 52 Weeks
59.91
Percentile Within Sector, Percent Change in Price, Past 26 Weeks
65.87
Percentile Within Sector, Percent Change in Price, Past 13 Weeks
70.13
Percentile Within Sector, Percent Change in Price, Past 4 Weeks
61.16
Percentile Within Sector, Percent Change in Price, Past 2 Weeks
66.40
Percentile Within Sector, Percent Change in Price, Past Week
72.89
Percentile Within Sector, Percent Change in Price, 1 Day
81.07
Percentiles Within Sector of Revenue/Net Income Growth
Percentile Within Sector, Percent Growth in Quarterly Revenue (QoQ)
10.48
Percentile Within Sector, Percent Growth in Quarterly Revenue (YoY)
54.77
Percentile Within Sector, Percent Growth in Annual Revenue
20.69
Percentile Within Sector, Percent Growth in Quarterly Net Income (QoQ)
22.14
Percentile Within Sector, Percent Growth in Quarterly Net Income (YoY)
46.77
Percentile Within Sector, Percent Growth in Annual Net Income
32.82
Percentiles Within Sector of Fundamental Ratios and Percentages
Percentile Within Sector, PE Ratio (Current Year Earnings Estimate)
Percentile Within Sector, PE Ratio (Trailing 12 Months)
Percentile Within Sector, PEG Ratio (Long Term Growth Estimate)
Percentile Within Sector, Price to Sales Ratio (Trailing 12 Months)
73.42
Percentile Within Sector, Price to Book Ratio (Most Recent Quarterly Book Value per Share)
90.59
Percentile Within Sector, Price to Cash Ratio (Most Recent Annual Cash Flow per Share)
Percentile Within Sector, Pre-Tax Margin (Trailing 12 Months)
45.03
Percentile Within Sector, Net Margin (Trailing 12 Months)
38.90
Percentile Within Sector, Return on Equity (Trailing 12 Months)
31.51
Percentile Within Sector, Return on Assets (Trailing 12 Months)
63.95
Percentile Within Sector, Current Ratio (Most Recent Fiscal Quarter)
83.14
Percentile Within Sector, Quick Ratio (Most Recent Fiscal Quarter)
83.18
Percentile Within Sector, Debt to Common Equity (Most Recent Fiscal Quarter)
94.22
Percentile Within Sector, Inventory Turnover (Trailing 12 Months)
9.70
Percentile Within Sector, Dividend Yield (Based on Last Quarter)
93.41
Percentile Within Sector, Percentage Held By Insiders (Latest Annual Proxy Report)
22.78
Percentile Within Sector, Percentage Held By Institutions (Latest 13F Reports)
87.40
Percentiles Within Market of Price Performance
Percentile Within Market, Percent Change in Price, Past 52 Weeks
24.41
Percentile Within Market, Percent Change in Price, Past 26 Weeks
44.56
Percentile Within Market, Percent Change in Price, Past 13 Weeks
73.57
Percentile Within Market, Percent Change in Price, Past 4 Weeks
83.92
Percentile Within Market, Percent Change in Price, Past 2 Weeks
84.69
Percentile Within Market, Percent Change in Price, Past Week
78.26
Percentile Within Market, Percent Change in Price, 1 Day
81.27
Percentiles Within Market of Revenue/Net Income Growth
Percentile Within Market, Percent Growth in Quarterly Revenue (QoQ)
4.81
Percentile Within Market, Percent Growth in Quarterly Revenue (YoY)
67.58
Percentile Within Market, Percent Growth in Annual Revenue
17.37
Percentile Within Market, Percent Growth in Quarterly Net Income (QoQ)
27.51
Percentile Within Market, Percent Growth in Quarterly Net Income (YoY)
44.46
Percentile Within Market, Percent Growth in Annual Net Income
32.34
Percentiles Within Market of Fundamental Ratios and Percentages
Percentile Within Market, PE Ratio (Current Year Earnings Estimate)
Percentile Within Market, PE Ratio (Trailing 12 Months)
Percentile Within Market, PEG Ratio (Long Term Growth Estimate)
Percentile Within Market, Price to Sales Ratio (Trailing 12 Months)
87.54
Percentile Within Market, Price to Book Ratio (Most Recent Quarterly Book Value per Share)
93.31
Percentile Within Market, Price to Cash Ratio (Most Recent Annual Cash Flow per Share)
Percentile Within Market, Pre-Tax Margin (Trailing 12 Months)
15.95
Percentile Within Market, Net Margin (Trailing 12 Months)
12.74
Percentile Within Market, Return on Equity (Trailing 12 Months)
11.84
Percentile Within Market, Return on Assets (Trailing 12 Months)
22.68
Percentile Within Market, Current Ratio (Most Recent Fiscal Quarter)
92.71
Percentile Within Market, Quick Ratio (Most Recent Fiscal Quarter)
93.04
Percentile Within Market, Debt to Common Equity (Most Recent Fiscal Quarter)
93.36
Percentile Within Market, Inventory Turnover (Trailing 12 Months)
4.20
Percentile Within Market, Dividend Yield (Based on Last Quarter)
61.76
Percentile Within Market, Percentage Held By Insiders (Latest Annual Proxy Report)
35.14
Percentile Within Market, Percentage Held By Institutions (Latest 13F Reports)
88.93