Karyopharm Therapeutics Inc. (KPTI)

Last Closing Price: 5.65 (2025-10-13)

Profile
Ticker
KPTI
Security Name
Karyopharm Therapeutics Inc.
Exchange
NASDAQ
Sector
Healthcare
Industry
Biotechnology
Free Float
8,413,000
Market Capitalization
50,470,000
Average Volume (Last 20 Days)
276,713
Beta (Past 60 Months)
0.34
Percentage Held By Insiders (Latest Annual Proxy Report)
2.98
Percentage Held By Institutions (Latest 13F Reports)
66.44
Recent Price/Volume
Closing Price
5.51
Opening Price
5.91
High Price
5.95
Low Price
5.50
Volume
213,000
Previous Closing Price
5.82
Previous Opening Price
5.61
Previous High Price
6.09
Previous Low Price
5.52
Previous Volume
652,000
High/Low Price
52-Week High Price
16.95
26-Week High Price
8.15
13-Week High Price
8.15
4-Week High Price
7.90
2-Week High Price
6.76
1-Week High Price
6.68
52-Week Low Price
3.51
26-Week Low Price
3.65
13-Week Low Price
3.65
4-Week Low Price
4.51
2-Week Low Price
4.51
1-Week Low Price
4.51
High/Low Volume
52-Week High Volume
3,133,000
26-Week High Volume
3,133,000
13-Week High Volume
3,133,000
4-Week High Volume
3,133,000
2-Week High Volume
3,133,000
1-Week High Volume
3,133,000
52-Week Low Volume
9,606
26-Week Low Volume
23,700
13-Week Low Volume
27,000
4-Week Low Volume
27,000
2-Week Low Volume
35,800
1-Week Low Volume
52,000
Money Flow
Total Money Flow, Past 52 Weeks
200,575,282
Total Money Flow, Past 26 Weeks
103,611,979
Total Money Flow, Past 13 Weeks
72,631,311
Total Money Flow, Past 4 Weeks
33,058,653
Total Money Flow, Past 2 Weeks
24,971,629
Total Money Flow, Past Week
23,359,629
Total Money Flow, 1 Day
1,204,160
Total Volume
Total Volume, Past 52 Weeks
30,882,871
Total Volume, Past 26 Weeks
19,579,271
Total Volume, Past 13 Weeks
13,203,700
Total Volume, Past 4 Weeks
5,682,500
Total Volume, Past 2 Weeks
4,436,300
Total Volume, Past Week
4,184,000
Percent Change in Price
Percent Change in Price, Past 52 Weeks
-57.35
Percent Change in Price, Past 26 Weeks
28.44
Percent Change in Price, Past 13 Weeks
21.10
Percent Change in Price, Past 4 Weeks
-14.57
Percent Change in Price, Past 2 Weeks
-15.88
Percent Change in Price, Past Week
-13.64
Percent Change in Price, 1 Day
-5.33
New High/Low in Price
Reached New 52-Week High Price
False
Reached New 26-Week High Price
False
Reached New 13-Week High Price
False
Reached New 4-Week High Price
False
Reached New 2-Week High Price
False
Reached New 1-Week High Price
False
Reached New 52-Week Low Price
False
Reached New 26-Week Low Price
False
Reached New 13-Week Low Price
False
Reached New 4-Week Low Price
False
Reached New 2-Week Low Price
False
Reached New 1-Week Low Price
False
Consecutive Days/Weeks of Increasing/Decreasing Price
Consecutive Days of Increasing Price
0
Consecutive Weeks of Increasing Price
0
Consecutive Days of Decreasing Price
2
Consecutive Weeks of Decreasing Price
2
Consecutive Days/Weeks of Increasing/Decreasing Volume
Consecutive Days of Increasing Volume
0
Consecutive Weeks of Increasing Volume
1
Consecutive Days of Decreasing Volume
2
Consecutive Weeks of Decreasing Volume
0
New High/Low in Volume
Had New 52-Week High Volume
False
Had New 26-Week High Volume
False
Had New 13-Week High Volume
False
Had New 4-Week High Volume
False
Had New 2-Week High Volume
False
Had New 1-Week High Volume
False
Had New 52-Week Low Volume
False
Had New 26-Week Low Volume
False
Had New 13-Week Low Volume
False
Had New 4-Week Low Volume
False
Had New 2-Week Low Volume
False
Had New 1-Week Low Volume
False
Moving Averages
Simple Moving Average (5-Day)
5.83
Simple Moving Average (10-Day)
6.09
Simple Moving Average (20-Day)
6.20
Simple Moving Average (50-Day)
5.93
Simple Moving Average (100-Day)
5.17
Simple Moving Average (200-Day)
6.34
Previous Simple Moving Average (5-Day)
6.01
Previous Simple Moving Average (10-Day)
6.20
Previous Simple Moving Average (20-Day)
6.25
Previous Simple Moving Average (50-Day)
5.90
Previous Simple Moving Average (100-Day)
5.16
Previous Simple Moving Average (200-Day)
6.36
Technical Indicators
MACD (12, 26, 9)
-0.08
MACD (12, 26, 9) Signal
0.05
Previous MACD (12, 26, 9)
-0.03
Previous MACD (12, 26, 9) Signal
0.08
RSI (14-Day)
41.55
Previous RSI (14-Day)
45.10
Stochastic (14, 3, 3) %K
36.38
Stochastic (14, 3, 3) %D
33.03
Previous Stochastic (14, 3, 3) %K
32.36
Previous Stochastic (14, 3, 3) %D
31.02
Upper Bollinger Band (20, 2)
7.15
Lower Bollinger Band (20, 2)
5.26
Previous Upper Bollinger Band (20, 2)
7.15
Previous Lower Bollinger Band (20, 2)
5.35
Income Statement Financials
Quarterly Revenue (MRQ)
37,929,000
Quarterly Net Income (MRQ)
-37,252,000
Previous Quarterly Revenue (QoQ)
30,015,000
Previous Quarterly Revenue (YoY)
42,786,000
Previous Quarterly Net Income (QoQ)
-23,462,000
Previous Quarterly Net Income (YoY)
23,792,000
Revenue (MRY)
145,237,000
Net Income (MRY)
-76,422,000
Previous Annual Revenue
146,033,000
Previous Net Income
-143,099,000
Cost of Goods Sold (MRY)
6,007,000
Gross Profit (MRY)
139,230,000
Operating Expenses (MRY)
264,680,000
Operating Income (MRY)
-119,443,000
Non-Operating Income/Expense (MRY)
43,078,000
Pre-Tax Income (MRY)
-76,365,000
Normalized Pre-Tax Income (MRY)
-76,365,000
Income after Taxes (MRY)
-76,422,000
Income from Continuous Operations (MRY)
-76,422,000
Consolidated Net Income/Loss (MRY)
-76,422,000
Normalized Income after Taxes (MRY)
-76,422,000
EBIT (MRY)
-119,443,000
EBITDA (MRY)
-115,238,000
Balance Sheet Financials
Current Assets (MRQ)
97,870,000
Property, Plant, and Equipment (MRQ)
244,000
Long-Term Assets (MRQ)
7,009,000
Total Assets (MRQ)
104,879,000
Current Liabilities (MRQ)
99,216,000
Long-Term Debt (MRQ)
152,250,000
Long-Term Liabilities (MRQ)
244,589,000
Total Liabilities (MRQ)
343,805,000
Common Equity (MRQ)
-238,926,100
Tangible Shareholders Equity (MRQ)
-238,926,000
Shareholders Equity (MRQ)
-238,926,000
Common Shares Outstanding (MRQ)
8,647,000
Cash Flow Statement Financials
Cash Flow from Operating Activities (MRY)
-127,486,000
Cash Flow from Investing Activities (MRY)
95,473,000
Cash Flow from Financial Activities (MRY)
41,646,000
Beginning Cash (MRY)
53,192,000
End Cash (MRY)
62,814,000
Increase/Decrease in Cash (MRY)
9,622,000
Fundamental Ratios
PE Ratio (Current Year Earnings Estimate)
PE Ratio (Trailing 12 Months)
PEG Ratio (Long Term Growth Estimate)
Price to Sales Ratio (Trailing 12 Months)
0.37
Price to Book Ratio (Most Recent Quarterly Book Value per Share)
Price to Cash Ratio (Most Recent Annual Cash Flow per Share)
Pre-Tax Margin (Trailing 12 Months)
-90.02
Net Margin (Trailing 12 Months)
-90.02
Return on Equity (Trailing 12 Months)
Return on Assets (Trailing 12 Months)
-84.28
Current Ratio (Most Recent Fiscal Quarter)
0.99
Quick Ratio (Most Recent Fiscal Quarter)
0.94
Debt to Common Equity (Most Recent Fiscal Quarter)
Inventory Turnover (Trailing 12 Months)
1.04
Book Value per Share (Most Recent Fiscal Quarter)
-22.10
Earnings
Fiscal Period End, Next Quarterly Earnings Report
2025-09-30
Quarterly Earnings per Share Estimate
-3.67
Next Expected Quarterly Earnings Report Date
2025-11-04
Days Until Next Expected Quarterly Earnings Report
24
Fiscal Period End, Last Quarterly Earnings Report
2025-06-30
Last Quarterly Earnings per Share Estimate
-3.80
Last Quarterly Earnings per Share
-4.32
Last Quarterly Earnings Report Date
2025-08-11
Days Since Last Quarterly Earnings Report
61
Earnings per Share (Most Recent Fiscal Year)
-13.94
Diluted Earnings per Share (Trailing 12 Months)
-14.59
Dividends
Last Dividend Date
Last Dividend Amount
Days Since Last Dividend
Annual Dividend (Based on Last Quarter)
0.00
Dividend Yield (Based on Last Quarter)
0.00
Percent Growth in Revenue/Net Income
Percent Growth in Quarterly Revenue (QoQ)
26.37
Percent Growth in Quarterly Revenue (YoY)
-11.35
Percent Growth in Annual Revenue
-0.55
Percent Growth in Quarterly Net Income (QoQ)
-58.78
Percent Growth in Quarterly Net Income (YoY)
-256.57
Percent Growth in Annual Net Income
46.60
New High/Low in Revenue/Net Income
New 5-Year High Annual Revenue
False
New 5-Year Low Annual Revenue
False
New 5-Year High Quarterly Revenue (QoQ)
False
New 5-Year Low Quarterly Revenue (QoQ)
False
New 5-Year High Quarterly Revenue (YoY)
False
New 5-Year Low Quarterly Revenue (YoY)
False
New 5-Year High Annual Net Income
True
New 5-Year Low Annual Net Income
False
New 5-Year High Quarterly Net Income (QoQ)
False
New 5-Year Low Quarterly Net Income (QoQ)
False
New 5-Year High Quarterly Net Income (YoY)
False
New 5-Year Low Quarterly Net Income (YoY)
False
Consecutive Quarters/Years of Increasing/Decreasing Revenue/Net Income
Consecutive Quarters of Increasing Revenue (QoQ)
1
Consecutive Quarters of Decreasing Revenue (QoQ)
0
Consecutive Quarters of Increasing Revenue (YoY)
0
Consecutive Quarters of Decreasing Revenue (YoY)
3
Consecutive Years of Increasing Revenue
0
Consecutive Years of Decreasing Revenue
3
Consecutive Quarters of Increasing Net Income (QoQ)
0
Consecutive Quarters of Decreasing Net Income (QoQ)
1
Consecutive Quarters of Increasing Net Income (YoY)
0
Consecutive Quarters of Decreasing Net Income (YoY)
1
Consecutive Years of Increasing Net Income
2
Consecutive Years of Decreasing Net Income
0
Splits
Last Split Date (if within past year)
2025-02-26
Last Split Ratio (if within past year)
0.07
Days Since Last Split (if within past year)
227
Volatility Metrics
Historical Volatility (Close-to-Close) (10-Day)
0.5552
Historical Volatility (Close-to-Close) (20-Day)
1.2650
Historical Volatility (Close-to-Close) (30-Day)
1.1072
Historical Volatility (Close-to-Close) (60-Day)
1.2140
Historical Volatility (Close-to-Close) (90-Day)
1.1725
Historical Volatility (Close-to-Close) (120-Day)
1.0829
Historical Volatility (Close-to-Close) (150-Day)
1.0187
Historical Volatility (Close-to-Close) (180-Day)
1.0599
Historical Volatility (Parkinson) (10-Day)
1.2863
Historical Volatility (Parkinson) (20-Day)
1.3776
Historical Volatility (Parkinson) (30-Day)
1.2068
Historical Volatility (Parkinson) (60-Day)
1.2322
Historical Volatility (Parkinson) (90-Day)
1.1583
Historical Volatility (Parkinson) (120-Day)
1.0999
Historical Volatility (Parkinson) (150-Day)
1.0474
Historical Volatility (Parkinson) (180-Day)
1.0616
Implied Volatility (Calls) (10-Day)
1.3967
Implied Volatility (Calls) (20-Day)
1.2153
Implied Volatility (Calls) (30-Day)
1.0338
Implied Volatility (Calls) (60-Day)
0.8864
Implied Volatility (Calls) (90-Day)
1.0034
Implied Volatility (Calls) (120-Day)
1.1209
Implied Volatility (Calls) (150-Day)
1.2868
Implied Volatility (Calls) (180-Day)
1.4904
Implied Volatility (Puts) (10-Day)
1.2814
Implied Volatility (Puts) (20-Day)
1.2899
Implied Volatility (Puts) (30-Day)
1.2983
Implied Volatility (Puts) (60-Day)
1.3127
Implied Volatility (Puts) (90-Day)
1.3197
Implied Volatility (Puts) (120-Day)
1.3260
Implied Volatility (Puts) (150-Day)
1.4400
Implied Volatility (Puts) (180-Day)
1.6351
Implied Volatility (Mean) (10-Day)
1.3391
Implied Volatility (Mean) (20-Day)
1.2526
Implied Volatility (Mean) (30-Day)
1.1661
Implied Volatility (Mean) (60-Day)
1.0995
Implied Volatility (Mean) (90-Day)
1.1616
Implied Volatility (Mean) (120-Day)
1.2234
Implied Volatility (Mean) (150-Day)
1.3634
Implied Volatility (Mean) (180-Day)
1.5628
Put-Call Implied Volatility Ratio (10-Day)
0.9175
Put-Call Implied Volatility Ratio (20-Day)
1.0614
Put-Call Implied Volatility Ratio (30-Day)
1.2558
Put-Call Implied Volatility Ratio (60-Day)
1.4809
Put-Call Implied Volatility Ratio (90-Day)
1.3152
Put-Call Implied Volatility Ratio (120-Day)
1.1830
Put-Call Implied Volatility Ratio (150-Day)
1.1191
Put-Call Implied Volatility Ratio (180-Day)
1.0971
Implied Volatility Skew (10-Day)
Implied Volatility Skew (20-Day)
Implied Volatility Skew (30-Day)
Implied Volatility Skew (60-Day)
-0.0481
Implied Volatility Skew (90-Day)
-0.0099
Implied Volatility Skew (120-Day)
0.0285
Implied Volatility Skew (150-Day)
0.0337
Implied Volatility Skew (180-Day)
0.0138
Option Statistics
Put-Call Ratio (Volume) (10-Day)
0.1273
Put-Call Ratio (Volume) (20-Day)
0.4398
Put-Call Ratio (Volume) (30-Day)
0.7523
Put-Call Ratio (Volume) (60-Day)
0.9043
Put-Call Ratio (Volume) (90-Day)
0.5327
Put-Call Ratio (Volume) (120-Day)
0.1610
Put-Call Ratio (Volume) (150-Day)
0.0000
Put-Call Ratio (Volume) (180-Day)
0.0000
Put-Call Ratio (Open Interest) (10-Day)
1.6647
Put-Call Ratio (Open Interest) (20-Day)
1.4681
Put-Call Ratio (Open Interest) (30-Day)
1.2714
Put-Call Ratio (Open Interest) (60-Day)
0.8755
Put-Call Ratio (Open Interest) (90-Day)
0.6089
Put-Call Ratio (Open Interest) (120-Day)
0.3422
Put-Call Ratio (Open Interest) (150-Day)
0.2018
Put-Call Ratio (Open Interest) (180-Day)
0.1579
Percentiles Within Industry of Price Performance
Percentile Within Industry, Percent Change in Price, Past 52 Weeks
23.06
Percentile Within Industry, Percent Change in Price, Past 26 Weeks
43.87
Percentile Within Industry, Percent Change in Price, Past 13 Weeks
54.35
Percentile Within Industry, Percent Change in Price, Past 4 Weeks
12.42
Percentile Within Industry, Percent Change in Price, Past 2 Weeks
6.29
Percentile Within Industry, Percent Change in Price, Past Week
7.10
Percentile Within Industry, Percent Change in Price, 1 Day
35.32
Percentiles Within Industry of Revenue/Net Income Growth
Percentile Within Industry, Percent Growth in Quarterly Revenue (QoQ)
67.43
Percentile Within Industry, Percent Growth in Quarterly Revenue (YoY)
27.71
Percentile Within Industry, Percent Growth in Annual Revenue
39.34
Percentile Within Industry, Percent Growth in Quarterly Net Income (QoQ)
16.90
Percentile Within Industry, Percent Growth in Quarterly Net Income (YoY)
7.79
Percentile Within Industry, Percent Growth in Annual Net Income
82.08
Percentiles Within Industry of Fundamental Ratios and Percentages
Percentile Within Industry, PE Ratio (Current Year Earnings Estimate)
Percentile Within Industry, PE Ratio (Trailing 12 Months)
Percentile Within Industry, PEG Ratio (Long Term Growth Estimate)
Percentile Within Industry, Price to Sales Ratio (Trailing 12 Months)
0.76
Percentile Within Industry, Price to Book Ratio (Most Recent Quarterly Book Value per Share)
Percentile Within Industry, Price to Cash Ratio (Most Recent Annual Cash Flow per Share)
Percentile Within Industry, Pre-Tax Margin (Trailing 12 Months)
69.37
Percentile Within Industry, Net Margin (Trailing 12 Months)
59.02
Percentile Within Industry, Return on Equity (Trailing 12 Months)
Percentile Within Industry, Return on Assets (Trailing 12 Months)
27.05
Percentile Within Industry, Current Ratio (Most Recent Fiscal Quarter)
10.28
Percentile Within Industry, Quick Ratio (Most Recent Fiscal Quarter)
10.14
Percentile Within Industry, Debt to Common Equity (Most Recent Fiscal Quarter)
Percentile Within Industry, Inventory Turnover (Trailing 12 Months)
38.36
Percentile Within Industry, Dividend Yield (Based on Last Quarter)
99.35
Percentile Within Industry, Percentage Held By Insiders (Latest Annual Proxy Report)
16.86
Percentile Within Industry, Percentage Held By Institutions (Latest 13F Reports)
64.53
Percentiles Within Sector of Price Performance
Percentile Within Sector, Percent Change in Price, Past 52 Weeks
20.28
Percentile Within Sector, Percent Change in Price, Past 26 Weeks
55.48
Percentile Within Sector, Percent Change in Price, Past 13 Weeks
64.15
Percentile Within Sector, Percent Change in Price, Past 4 Weeks
12.90
Percentile Within Sector, Percent Change in Price, Past 2 Weeks
5.99
Percentile Within Sector, Percent Change in Price, Past Week
6.54
Percentile Within Sector, Percent Change in Price, 1 Day
33.46
Percentiles Within Sector of Revenue/Net Income Growth
Percentile Within Sector, Percent Growth in Quarterly Revenue (QoQ)
82.32
Percentile Within Sector, Percent Growth in Quarterly Revenue (YoY)
18.41
Percentile Within Sector, Percent Growth in Annual Revenue
31.40
Percentile Within Sector, Percent Growth in Quarterly Net Income (QoQ)
16.67
Percentile Within Sector, Percent Growth in Quarterly Net Income (YoY)
8.71
Percentile Within Sector, Percent Growth in Annual Net Income
79.81
Percentiles Within Sector of Fundamental Ratios and Percentages
Percentile Within Sector, PE Ratio (Current Year Earnings Estimate)
Percentile Within Sector, PE Ratio (Trailing 12 Months)
Percentile Within Sector, PEG Ratio (Long Term Growth Estimate)
Percentile Within Sector, Price to Sales Ratio (Trailing 12 Months)
5.52
Percentile Within Sector, Price to Book Ratio (Most Recent Quarterly Book Value per Share)
Percentile Within Sector, Price to Cash Ratio (Most Recent Annual Cash Flow per Share)
Percentile Within Sector, Pre-Tax Margin (Trailing 12 Months)
41.64
Percentile Within Sector, Net Margin (Trailing 12 Months)
32.12
Percentile Within Sector, Return on Equity (Trailing 12 Months)
Percentile Within Sector, Return on Assets (Trailing 12 Months)
19.90
Percentile Within Sector, Current Ratio (Most Recent Fiscal Quarter)
12.36
Percentile Within Sector, Quick Ratio (Most Recent Fiscal Quarter)
15.53
Percentile Within Sector, Debt to Common Equity (Most Recent Fiscal Quarter)
Percentile Within Sector, Inventory Turnover (Trailing 12 Months)
19.87
Percentile Within Sector, Dividend Yield (Based on Last Quarter)
93.07
Percentile Within Sector, Percentage Held By Insiders (Latest Annual Proxy Report)
24.83
Percentile Within Sector, Percentage Held By Institutions (Latest 13F Reports)
59.77
Percentiles Within Market of Price Performance
Percentile Within Market, Percent Change in Price, Past 52 Weeks
6.46
Percentile Within Market, Percent Change in Price, Past 26 Weeks
72.90
Percentile Within Market, Percent Change in Price, Past 13 Weeks
86.64
Percentile Within Market, Percent Change in Price, Past 4 Weeks
8.27
Percentile Within Market, Percent Change in Price, Past 2 Weeks
3.98
Percentile Within Market, Percent Change in Price, Past Week
4.23
Percentile Within Market, Percent Change in Price, 1 Day
17.74
Percentiles Within Market of Revenue/Net Income Growth
Percentile Within Market, Percent Growth in Quarterly Revenue (QoQ)
88.72
Percentile Within Market, Percent Growth in Quarterly Revenue (YoY)
13.96
Percentile Within Market, Percent Growth in Annual Revenue
34.96
Percentile Within Market, Percent Growth in Quarterly Net Income (QoQ)
17.95
Percentile Within Market, Percent Growth in Quarterly Net Income (YoY)
7.33
Percentile Within Market, Percent Growth in Annual Net Income
75.05
Percentiles Within Market of Fundamental Ratios and Percentages
Percentile Within Market, PE Ratio (Current Year Earnings Estimate)
Percentile Within Market, PE Ratio (Trailing 12 Months)
Percentile Within Market, PEG Ratio (Long Term Growth Estimate)
Percentile Within Market, Price to Sales Ratio (Trailing 12 Months)
10.59
Percentile Within Market, Price to Book Ratio (Most Recent Quarterly Book Value per Share)
Percentile Within Market, Price to Cash Ratio (Most Recent Annual Cash Flow per Share)
Percentile Within Market, Pre-Tax Margin (Trailing 12 Months)
12.97
Percentile Within Market, Net Margin (Trailing 12 Months)
10.10
Percentile Within Market, Return on Equity (Trailing 12 Months)
Percentile Within Market, Return on Assets (Trailing 12 Months)
5.98
Percentile Within Market, Current Ratio (Most Recent Fiscal Quarter)
25.98
Percentile Within Market, Quick Ratio (Most Recent Fiscal Quarter)
33.13
Percentile Within Market, Debt to Common Equity (Most Recent Fiscal Quarter)
Percentile Within Market, Inventory Turnover (Trailing 12 Months)
7.94
Percentile Within Market, Dividend Yield (Based on Last Quarter)
61.82
Percentile Within Market, Percentage Held By Insiders (Latest Annual Proxy Report)
37.72
Percentile Within Market, Percentage Held By Institutions (Latest 13F Reports)
56.30