Spyre Therapeutics, Inc. (SYRE)

Last Closing Price: 16.72 (2025-08-28)

Profile
Ticker
SYRE
Security Name
Spyre Therapeutics, Inc.
Exchange
NASDAQ
Sector
Healthcare
Industry
Biotechnology
Free Float
51,081,000
Market Capitalization
1,035,270,000
Average Volume (Last 20 Days)
481,175
Beta (Past 60 Months)
2.82
Percentage Held By Insiders (Latest Annual Proxy Report)
15.43
Percentage Held By Institutions (Latest 13F Reports)
80.39
Recent Price/Volume
Closing Price
16.72
Opening Price
17.18
High Price
17.39
Low Price
16.65
Volume
272,000
Previous Closing Price
17.14
Previous Opening Price
16.91
Previous High Price
17.34
Previous Low Price
16.89
Previous Volume
329,000
High/Low Price
52-Week High Price
40.26
26-Week High Price
21.03
13-Week High Price
18.83
4-Week High Price
17.80
2-Week High Price
17.80
1-Week High Price
17.80
52-Week Low Price
10.91
26-Week Low Price
10.91
13-Week Low Price
13.93
4-Week Low Price
14.72
2-Week Low Price
15.73
1-Week Low Price
16.38
High/Low Volume
52-Week High Volume
3,123,518
26-Week High Volume
1,641,775
13-Week High Volume
1,332,000
4-Week High Volume
806,000
2-Week High Volume
806,000
1-Week High Volume
806,000
52-Week Low Volume
186,732
26-Week Low Volume
210,226
13-Week Low Volume
213,000
4-Week Low Volume
213,000
2-Week Low Volume
272,000
1-Week Low Volume
272,000
Money Flow
Total Money Flow, Past 52 Weeks
3,061,713,257
Total Money Flow, Past 26 Weeks
1,187,450,832
Total Money Flow, Past 13 Weeks
540,257,193
Total Money Flow, Past 4 Weeks
150,896,887
Total Money Flow, Past 2 Weeks
82,100,965
Total Money Flow, Past Week
36,690,265
Total Money Flow, 1 Day
4,602,240
Total Volume
Total Volume, Past 52 Weeks
144,714,610
Total Volume, Past 26 Weeks
74,946,843
Total Volume, Past 13 Weeks
33,107,000
Total Volume, Past 4 Weeks
9,137,000
Total Volume, Past 2 Weeks
4,887,000
Total Volume, Past Week
2,149,000
Percent Change in Price
Percent Change in Price, Past 52 Weeks
-40.43
Percent Change in Price, Past 26 Weeks
-8.98
Percent Change in Price, Past 13 Weeks
7.52
Percent Change in Price, Past 4 Weeks
-1.47
Percent Change in Price, Past 2 Weeks
-0.83
Percent Change in Price, Past Week
-0.36
Percent Change in Price, 1 Day
-2.45
New High/Low in Price
Reached New 52-Week High Price
False
Reached New 26-Week High Price
False
Reached New 13-Week High Price
False
Reached New 4-Week High Price
False
Reached New 2-Week High Price
False
Reached New 1-Week High Price
False
Reached New 52-Week Low Price
False
Reached New 26-Week Low Price
False
Reached New 13-Week Low Price
False
Reached New 4-Week Low Price
False
Reached New 2-Week Low Price
False
Reached New 1-Week Low Price
False
Consecutive Days/Weeks of Increasing/Decreasing Price
Consecutive Days of Increasing Price
0
Consecutive Weeks of Increasing Price
0
Consecutive Days of Decreasing Price
1
Consecutive Weeks of Decreasing Price
2
Consecutive Days/Weeks of Increasing/Decreasing Volume
Consecutive Days of Increasing Volume
0
Consecutive Weeks of Increasing Volume
2
Consecutive Days of Decreasing Volume
2
Consecutive Weeks of Decreasing Volume
0
New High/Low in Volume
Had New 52-Week High Volume
False
Had New 26-Week High Volume
False
Had New 13-Week High Volume
False
Had New 4-Week High Volume
False
Had New 2-Week High Volume
False
Had New 1-Week High Volume
False
Had New 52-Week Low Volume
False
Had New 26-Week Low Volume
False
Had New 13-Week Low Volume
False
Had New 4-Week Low Volume
False
Had New 2-Week Low Volume
True
Had New 1-Week Low Volume
True
Moving Averages
Simple Moving Average (5-Day)
16.98
Simple Moving Average (10-Day)
16.80
Simple Moving Average (20-Day)
16.45
Simple Moving Average (50-Day)
16.24
Simple Moving Average (100-Day)
15.50
Simple Moving Average (200-Day)
19.19
Previous Simple Moving Average (5-Day)
16.99
Previous Simple Moving Average (10-Day)
16.81
Previous Simple Moving Average (20-Day)
16.47
Previous Simple Moving Average (50-Day)
16.21
Previous Simple Moving Average (100-Day)
15.46
Previous Simple Moving Average (200-Day)
19.29
Technical Indicators
MACD (12, 26, 9)
0.16
MACD (12, 26, 9) Signal
0.12
Previous MACD (12, 26, 9)
0.18
Previous MACD (12, 26, 9) Signal
0.11
RSI (14-Day)
51.14
Previous RSI (14-Day)
54.55
Stochastic (14, 3, 3) %K
73.15
Stochastic (14, 3, 3) %D
73.01
Previous Stochastic (14, 3, 3) %K
71.64
Previous Stochastic (14, 3, 3) %D
73.40
Upper Bollinger Band (20, 2)
17.80
Lower Bollinger Band (20, 2)
15.11
Previous Upper Bollinger Band (20, 2)
17.82
Previous Lower Bollinger Band (20, 2)
15.11
Income Statement Financials
Quarterly Revenue (MRQ)
Quarterly Net Income (MRQ)
-36,717,000
Previous Quarterly Revenue (QoQ)
Previous Quarterly Revenue (YoY)
Previous Quarterly Net Income (QoQ)
-44,773,000
Previous Quarterly Net Income (YoY)
-38,837,000
Revenue (MRY)
Net Income (MRY)
-208,018,000
Previous Annual Revenue
886,000
Previous Net Income
-338,790,000
Cost of Goods Sold (MRY)
Gross Profit (MRY)
Operating Expenses (MRY)
208,566,000
Operating Income (MRY)
-208,566,000
Non-Operating Income/Expense (MRY)
599,000
Pre-Tax Income (MRY)
-207,967,000
Normalized Pre-Tax Income (MRY)
-207,967,000
Income after Taxes (MRY)
-208,018,000
Income from Continuous Operations (MRY)
-208,018,000
Consolidated Net Income/Loss (MRY)
-208,018,000
Normalized Income after Taxes (MRY)
-208,018,000
EBIT (MRY)
-208,566,000
EBITDA (MRY)
-219,970,000
Balance Sheet Financials
Current Assets (MRQ)
538,832,000
Property, Plant, and Equipment (MRQ)
Long-Term Assets (MRQ)
Total Assets (MRQ)
538,832,000
Current Liabilities (MRQ)
83,059,000
Long-Term Debt (MRQ)
Long-Term Liabilities (MRQ)
Total Liabilities (MRQ)
83,059,000
Common Equity (MRQ)
299,952,900
Tangible Shareholders Equity (MRQ)
455,773,000
Shareholders Equity (MRQ)
455,773,000
Common Shares Outstanding (MRQ)
60,372,900
Cash Flow Statement Financials
Cash Flow from Operating Activities (MRY)
-157,410,000
Cash Flow from Investing Activities (MRY)
-353,285,000
Cash Flow from Financial Activities (MRY)
410,906,000
Beginning Cash (MRY)
189,215,000
End Cash (MRY)
89,423,000
Increase/Decrease in Cash (MRY)
-99,792,000
Fundamental Ratios
PE Ratio (Current Year Earnings Estimate)
PE Ratio (Trailing 12 Months)
PEG Ratio (Long Term Growth Estimate)
Price to Sales Ratio (Trailing 12 Months)
Price to Book Ratio (Most Recent Quarterly Book Value per Share)
3.44
Price to Cash Ratio (Most Recent Annual Cash Flow per Share)
Pre-Tax Margin (Trailing 12 Months)
Net Margin (Trailing 12 Months)
Return on Equity (Trailing 12 Months)
-71.30
Return on Assets (Trailing 12 Months)
-38.69
Current Ratio (Most Recent Fiscal Quarter)
6.49
Quick Ratio (Most Recent Fiscal Quarter)
6.49
Debt to Common Equity (Most Recent Fiscal Quarter)
0.00
Inventory Turnover (Trailing 12 Months)
Book Value per Share (Most Recent Fiscal Quarter)
4.97
Earnings
Fiscal Period End, Next Quarterly Earnings Report
2025-09-30
Quarterly Earnings per Share Estimate
-0.75
Next Expected Quarterly Earnings Report Date
2025-11-06
Days Until Next Expected Quarterly Earnings Report
69
Fiscal Period End, Last Quarterly Earnings Report
2025-06-30
Last Quarterly Earnings per Share Estimate
-0.73
Last Quarterly Earnings per Share
-0.49
Last Quarterly Earnings Report Date
2025-08-05
Days Since Last Quarterly Earnings Report
24
Earnings per Share (Most Recent Fiscal Year)
-3.18
Diluted Earnings per Share (Trailing 12 Months)
-3.40
Dividends
Last Dividend Date
Last Dividend Amount
Days Since Last Dividend
Annual Dividend (Based on Last Quarter)
0.00
Dividend Yield (Based on Last Quarter)
0.00
Percent Growth in Revenue/Net Income
Percent Growth in Quarterly Revenue (QoQ)
Percent Growth in Quarterly Revenue (YoY)
Percent Growth in Annual Revenue
Percent Growth in Quarterly Net Income (QoQ)
17.99
Percent Growth in Quarterly Net Income (YoY)
5.46
Percent Growth in Annual Net Income
38.60
New High/Low in Revenue/Net Income
New 5-Year High Annual Revenue
False
New 5-Year Low Annual Revenue
False
New 5-Year High Quarterly Revenue (QoQ)
False
New 5-Year Low Quarterly Revenue (QoQ)
False
New 5-Year High Quarterly Revenue (YoY)
False
New 5-Year Low Quarterly Revenue (YoY)
False
New 5-Year High Annual Net Income
False
New 5-Year Low Annual Net Income
False
New 5-Year High Quarterly Net Income (QoQ)
False
New 5-Year Low Quarterly Net Income (QoQ)
False
New 5-Year High Quarterly Net Income (YoY)
False
New 5-Year Low Quarterly Net Income (YoY)
False
Consecutive Quarters/Years of Increasing/Decreasing Revenue/Net Income
Consecutive Quarters of Increasing Revenue (QoQ)
2
Consecutive Quarters of Decreasing Revenue (QoQ)
0
Consecutive Quarters of Increasing Revenue (YoY)
0
Consecutive Quarters of Decreasing Revenue (YoY)
1
Consecutive Years of Increasing Revenue
0
Consecutive Years of Decreasing Revenue
3
Consecutive Quarters of Increasing Net Income (QoQ)
3
Consecutive Quarters of Decreasing Net Income (QoQ)
0
Consecutive Quarters of Increasing Net Income (YoY)
1
Consecutive Quarters of Decreasing Net Income (YoY)
0
Consecutive Years of Increasing Net Income
1
Consecutive Years of Decreasing Net Income
0
Splits
Last Split Date (if within past year)
Last Split Ratio (if within past year)
Days Since Last Split (if within past year)
Volatility Metrics
Historical Volatility (Close-to-Close) (10-Day)
0.5467
Historical Volatility (Close-to-Close) (20-Day)
0.6009
Historical Volatility (Close-to-Close) (30-Day)
0.5954
Historical Volatility (Close-to-Close) (60-Day)
0.5951
Historical Volatility (Close-to-Close) (90-Day)
0.6255
Historical Volatility (Close-to-Close) (120-Day)
0.6454
Historical Volatility (Close-to-Close) (150-Day)
0.7144
Historical Volatility (Close-to-Close) (180-Day)
0.7207
Historical Volatility (Parkinson) (10-Day)
0.4831
Historical Volatility (Parkinson) (20-Day)
0.5068
Historical Volatility (Parkinson) (30-Day)
0.5251
Historical Volatility (Parkinson) (60-Day)
0.5842
Historical Volatility (Parkinson) (90-Day)
0.6546
Historical Volatility (Parkinson) (120-Day)
0.6545
Historical Volatility (Parkinson) (150-Day)
0.7120
Historical Volatility (Parkinson) (180-Day)
0.7225
Implied Volatility (Calls) (10-Day)
1.5086
Implied Volatility (Calls) (20-Day)
1.5086
Implied Volatility (Calls) (30-Day)
1.3644
Implied Volatility (Calls) (60-Day)
0.9613
Implied Volatility (Calls) (90-Day)
0.8331
Implied Volatility (Calls) (120-Day)
0.7306
Implied Volatility (Calls) (150-Day)
0.7126
Implied Volatility (Calls) (180-Day)
0.6948
Implied Volatility (Puts) (10-Day)
1.1348
Implied Volatility (Puts) (20-Day)
1.1348
Implied Volatility (Puts) (30-Day)
1.1153
Implied Volatility (Puts) (60-Day)
1.0180
Implied Volatility (Puts) (90-Day)
0.8727
Implied Volatility (Puts) (120-Day)
0.7565
Implied Volatility (Puts) (150-Day)
0.7364
Implied Volatility (Puts) (180-Day)
0.7158
Implied Volatility (Mean) (10-Day)
1.3217
Implied Volatility (Mean) (20-Day)
1.3217
Implied Volatility (Mean) (30-Day)
1.2398
Implied Volatility (Mean) (60-Day)
0.9896
Implied Volatility (Mean) (90-Day)
0.8529
Implied Volatility (Mean) (120-Day)
0.7435
Implied Volatility (Mean) (150-Day)
0.7245
Implied Volatility (Mean) (180-Day)
0.7053
Put-Call Implied Volatility Ratio (10-Day)
0.7522
Put-Call Implied Volatility Ratio (20-Day)
0.7522
Put-Call Implied Volatility Ratio (30-Day)
0.8174
Put-Call Implied Volatility Ratio (60-Day)
1.0590
Put-Call Implied Volatility Ratio (90-Day)
1.0475
Put-Call Implied Volatility Ratio (120-Day)
1.0353
Put-Call Implied Volatility Ratio (150-Day)
1.0335
Put-Call Implied Volatility Ratio (180-Day)
1.0302
Implied Volatility Skew (10-Day)
-0.6457
Implied Volatility Skew (20-Day)
-0.6457
Implied Volatility Skew (30-Day)
-0.4478
Implied Volatility Skew (60-Day)
0.0516
Implied Volatility Skew (90-Day)
0.0653
Implied Volatility Skew (120-Day)
0.0768
Implied Volatility Skew (150-Day)
0.0811
Implied Volatility Skew (180-Day)
0.0855
Option Statistics
Put-Call Ratio (Volume) (10-Day)
Put-Call Ratio (Volume) (20-Day)
Put-Call Ratio (Volume) (30-Day)
Put-Call Ratio (Volume) (60-Day)
Put-Call Ratio (Volume) (90-Day)
Put-Call Ratio (Volume) (120-Day)
0.0000
Put-Call Ratio (Volume) (150-Day)
0.0000
Put-Call Ratio (Volume) (180-Day)
0.0000
Put-Call Ratio (Open Interest) (10-Day)
0.0384
Put-Call Ratio (Open Interest) (20-Day)
0.0384
Put-Call Ratio (Open Interest) (30-Day)
0.0274
Put-Call Ratio (Open Interest) (60-Day)
0.0220
Put-Call Ratio (Open Interest) (90-Day)
0.0878
Put-Call Ratio (Open Interest) (120-Day)
0.2046
Put-Call Ratio (Open Interest) (150-Day)
0.4887
Put-Call Ratio (Open Interest) (180-Day)
0.7727
Percentiles Within Industry of Price Performance
Percentile Within Industry, Percent Change in Price, Past 52 Weeks
40.35
Percentile Within Industry, Percent Change in Price, Past 26 Weeks
39.71
Percentile Within Industry, Percent Change in Price, Past 13 Weeks
46.89
Percentile Within Industry, Percent Change in Price, Past 4 Weeks
39.07
Percentile Within Industry, Percent Change in Price, Past 2 Weeks
41.79
Percentile Within Industry, Percent Change in Price, Past Week
40.19
Percentile Within Industry, Percent Change in Price, 1 Day
21.85
Percentiles Within Industry of Revenue/Net Income Growth
Percentile Within Industry, Percent Growth in Quarterly Revenue (QoQ)
Percentile Within Industry, Percent Growth in Quarterly Revenue (YoY)
Percentile Within Industry, Percent Growth in Annual Revenue
Percentile Within Industry, Percent Growth in Quarterly Net Income (QoQ)
71.36
Percentile Within Industry, Percent Growth in Quarterly Net Income (YoY)
56.24
Percentile Within Industry, Percent Growth in Annual Net Income
77.40
Percentiles Within Industry of Fundamental Ratios and Percentages
Percentile Within Industry, PE Ratio (Current Year Earnings Estimate)
Percentile Within Industry, PE Ratio (Trailing 12 Months)
Percentile Within Industry, PEG Ratio (Long Term Growth Estimate)
Percentile Within Industry, Price to Sales Ratio (Trailing 12 Months)
Percentile Within Industry, Price to Book Ratio (Most Recent Quarterly Book Value per Share)
65.48
Percentile Within Industry, Price to Cash Ratio (Most Recent Annual Cash Flow per Share)
Percentile Within Industry, Pre-Tax Margin (Trailing 12 Months)
Percentile Within Industry, Net Margin (Trailing 12 Months)
Percentile Within Industry, Return on Equity (Trailing 12 Months)
48.95
Percentile Within Industry, Return on Assets (Trailing 12 Months)
59.28
Percentile Within Industry, Current Ratio (Most Recent Fiscal Quarter)
62.98
Percentile Within Industry, Quick Ratio (Most Recent Fiscal Quarter)
63.45
Percentile Within Industry, Debt to Common Equity (Most Recent Fiscal Quarter)
71.28
Percentile Within Industry, Inventory Turnover (Trailing 12 Months)
Percentile Within Industry, Dividend Yield (Based on Last Quarter)
99.36
Percentile Within Industry, Percentage Held By Insiders (Latest Annual Proxy Report)
67.71
Percentile Within Industry, Percentage Held By Institutions (Latest 13F Reports)
75.83
Percentiles Within Sector of Price Performance
Percentile Within Sector, Percent Change in Price, Past 52 Weeks
34.73
Percentile Within Sector, Percent Change in Price, Past 26 Weeks
42.60
Percentile Within Sector, Percent Change in Price, Past 13 Weeks
51.10
Percentile Within Sector, Percent Change in Price, Past 4 Weeks
36.29
Percentile Within Sector, Percent Change in Price, Past 2 Weeks
38.12
Percentile Within Sector, Percent Change in Price, Past Week
37.20
Percentile Within Sector, Percent Change in Price, 1 Day
17.82
Percentiles Within Sector of Revenue/Net Income Growth
Percentile Within Sector, Percent Growth in Quarterly Revenue (QoQ)
Percentile Within Sector, Percent Growth in Quarterly Revenue (YoY)
Percentile Within Sector, Percent Growth in Annual Revenue
Percentile Within Sector, Percent Growth in Quarterly Net Income (QoQ)
65.34
Percentile Within Sector, Percent Growth in Quarterly Net Income (YoY)
52.82
Percentile Within Sector, Percent Growth in Annual Net Income
75.77
Percentiles Within Sector of Fundamental Ratios and Percentages
Percentile Within Sector, PE Ratio (Current Year Earnings Estimate)
Percentile Within Sector, PE Ratio (Trailing 12 Months)
Percentile Within Sector, PEG Ratio (Long Term Growth Estimate)
Percentile Within Sector, Price to Sales Ratio (Trailing 12 Months)
Percentile Within Sector, Price to Book Ratio (Most Recent Quarterly Book Value per Share)
65.02
Percentile Within Sector, Price to Cash Ratio (Most Recent Annual Cash Flow per Share)
Percentile Within Sector, Pre-Tax Margin (Trailing 12 Months)
Percentile Within Sector, Net Margin (Trailing 12 Months)
Percentile Within Sector, Return on Equity (Trailing 12 Months)
38.31
Percentile Within Sector, Return on Assets (Trailing 12 Months)
43.43
Percentile Within Sector, Current Ratio (Most Recent Fiscal Quarter)
73.79
Percentile Within Sector, Quick Ratio (Most Recent Fiscal Quarter)
75.09
Percentile Within Sector, Debt to Common Equity (Most Recent Fiscal Quarter)
56.16
Percentile Within Sector, Inventory Turnover (Trailing 12 Months)
Percentile Within Sector, Dividend Yield (Based on Last Quarter)
93.04
Percentile Within Sector, Percentage Held By Insiders (Latest Annual Proxy Report)
70.17
Percentile Within Sector, Percentage Held By Institutions (Latest 13F Reports)
71.88
Percentiles Within Market of Price Performance
Percentile Within Market, Percent Change in Price, Past 52 Weeks
10.87
Percentile Within Market, Percent Change in Price, Past 26 Weeks
19.15
Percentile Within Market, Percent Change in Price, Past 13 Weeks
54.17
Percentile Within Market, Percent Change in Price, Past 4 Weeks
19.69
Percentile Within Market, Percent Change in Price, Past 2 Weeks
20.09
Percentile Within Market, Percent Change in Price, Past Week
16.40
Percentile Within Market, Percent Change in Price, 1 Day
6.26
Percentiles Within Market of Revenue/Net Income Growth
Percentile Within Market, Percent Growth in Quarterly Revenue (QoQ)
Percentile Within Market, Percent Growth in Quarterly Revenue (YoY)
Percentile Within Market, Percent Growth in Annual Revenue
Percentile Within Market, Percent Growth in Quarterly Net Income (QoQ)
59.11
Percentile Within Market, Percent Growth in Quarterly Net Income (YoY)
49.41
Percentile Within Market, Percent Growth in Annual Net Income
72.13
Percentiles Within Market of Fundamental Ratios and Percentages
Percentile Within Market, PE Ratio (Current Year Earnings Estimate)
Percentile Within Market, PE Ratio (Trailing 12 Months)
Percentile Within Market, PEG Ratio (Long Term Growth Estimate)
Percentile Within Market, Price to Sales Ratio (Trailing 12 Months)
Percentile Within Market, Price to Book Ratio (Most Recent Quarterly Book Value per Share)
70.43
Percentile Within Market, Price to Cash Ratio (Most Recent Annual Cash Flow per Share)
Percentile Within Market, Pre-Tax Margin (Trailing 12 Months)
Percentile Within Market, Net Margin (Trailing 12 Months)
Percentile Within Market, Return on Equity (Trailing 12 Months)
14.31
Percentile Within Market, Return on Assets (Trailing 12 Months)
14.01
Percentile Within Market, Current Ratio (Most Recent Fiscal Quarter)
89.05
Percentile Within Market, Quick Ratio (Most Recent Fiscal Quarter)
89.89
Percentile Within Market, Debt to Common Equity (Most Recent Fiscal Quarter)
31.90
Percentile Within Market, Inventory Turnover (Trailing 12 Months)
Percentile Within Market, Dividend Yield (Based on Last Quarter)
61.71
Percentile Within Market, Percentage Held By Insiders (Latest Annual Proxy Report)
71.36
Percentile Within Market, Percentage Held By Institutions (Latest 13F Reports)
69.63