Spyre Therapeutics, Inc. (SYRE)

Last Closing Price: 87.05 (2026-09-02)

Profile
Ticker
SYRE
Security Name
Spyre Therapeutics, Inc.
Exchange
NASDAQ
Sector
Healthcare
Industry
Biotechnology
Free Float
74,139,000
Market Capitalization
7,782,380,000
Average Volume (Last 20 Days)
1,047,211
Beta (Past 60 Months)
2.99
Percentage Held By Insiders (Latest Annual Proxy Report)
15.69
Percentage Held By Institutions (Latest 13F Reports)
80.39
Recent Price/Volume
Closing Price
87.05
Opening Price
88.05
High Price
90.18
Low Price
85.00
Volume
1,362,000
Previous Closing Price
88.50
Previous Opening Price
87.06
Previous High Price
90.00
Previous Low Price
85.00
Previous Volume
1,429,000
High/Low Price
52-Week High Price
110.17
26-Week High Price
110.17
13-Week High Price
110.17
4-Week High Price
110.17
2-Week High Price
110.15
1-Week High Price
94.94
52-Week Low Price
14.51
26-Week Low Price
38.36
13-Week Low Price
70.89
4-Week Low Price
85.00
2-Week Low Price
85.00
1-Week Low Price
85.00
High/Low Volume
52-Week High Volume
5,560,000
26-Week High Volume
5,361,000
13-Week High Volume
4,441,000
4-Week High Volume
3,114,000
2-Week High Volume
3,114,000
1-Week High Volume
1,913,000
52-Week Low Volume
245,000
26-Week Low Volume
429,000
13-Week Low Volume
444,000
4-Week Low Volume
444,000
2-Week Low Volume
641,000
1-Week Low Volume
1,165,000
Money Flow
Total Money Flow, Past 52 Weeks
14,783,797,541
Total Money Flow, Past 26 Weeks
12,055,889,051
Total Money Flow, Past 13 Weeks
7,683,152,358
Total Money Flow, Past 4 Weeks
2,058,522,962
Total Money Flow, Past 2 Weeks
1,281,788,645
Total Money Flow, Past Week
638,578,715
Total Money Flow, 1 Day
119,052,420
Total Volume
Total Volume, Past 52 Weeks
252,090,000
Total Volume, Past 26 Weeks
151,996,000
Total Volume, Past 13 Weeks
82,800,000
Total Volume, Past 4 Weeks
20,974,000
Total Volume, Past 2 Weeks
13,530,000
Total Volume, Past Week
7,135,000
Percent Change in Price
Percent Change in Price, Past 52 Weeks
417.85
Percent Change in Price, Past 26 Weeks
112.32
Percent Change in Price, Past 13 Weeks
18.40
Percent Change in Price, Past 4 Weeks
-16.58
Percent Change in Price, Past 2 Weeks
-20.08
Percent Change in Price, Past Week
-7.00
Percent Change in Price, 1 Day
-1.64
New High/Low in Price
Reached New 52-Week High Price
False
Reached New 26-Week High Price
False
Reached New 13-Week High Price
False
Reached New 4-Week High Price
False
Reached New 2-Week High Price
False
Reached New 1-Week High Price
False
Reached New 52-Week Low Price
False
Reached New 26-Week Low Price
False
Reached New 13-Week Low Price
False
Reached New 4-Week Low Price
False
Reached New 2-Week Low Price
False
Reached New 1-Week Low Price
False
Consecutive Days/Weeks of Increasing/Decreasing Price
Consecutive Days of Increasing Price
0
Consecutive Weeks of Increasing Price
0
Consecutive Days of Decreasing Price
4
Consecutive Weeks of Decreasing Price
2
Consecutive Days/Weeks of Increasing/Decreasing Volume
Consecutive Days of Increasing Volume
0
Consecutive Weeks of Increasing Volume
3
Consecutive Days of Decreasing Volume
2
Consecutive Weeks of Decreasing Volume
0
New High/Low in Volume
Had New 52-Week High Volume
False
Had New 26-Week High Volume
False
Had New 13-Week High Volume
False
Had New 4-Week High Volume
False
Had New 2-Week High Volume
False
Had New 1-Week High Volume
False
Had New 52-Week Low Volume
False
Had New 26-Week Low Volume
False
Had New 13-Week Low Volume
False
Had New 4-Week Low Volume
False
Had New 2-Week Low Volume
False
Had New 1-Week Low Volume
False
Moving Averages
Simple Moving Average (5-Day)
89.77
Simple Moving Average (10-Day)
97.08
Simple Moving Average (20-Day)
100.90
Simple Moving Average (50-Day)
98.05
Simple Moving Average (100-Day)
86.33
Simple Moving Average (200-Day)
61.34
Previous Simple Moving Average (5-Day)
91.08
Previous Simple Moving Average (10-Day)
99.26
Previous Simple Moving Average (20-Day)
101.77
Previous Simple Moving Average (50-Day)
98.25
Previous Simple Moving Average (100-Day)
85.98
Previous Simple Moving Average (200-Day)
61.02
Technical Indicators
MACD (12, 26, 9)
-2.48
MACD (12, 26, 9) Signal
0.04
Previous MACD (12, 26, 9)
-1.81
Previous MACD (12, 26, 9) Signal
0.67
RSI (14-Day)
32.27
Previous RSI (14-Day)
33.73
Stochastic (14, 3, 3) %K
11.46
Stochastic (14, 3, 3) %D
10.79
Previous Stochastic (14, 3, 3) %K
10.21
Previous Stochastic (14, 3, 3) %D
10.88
Upper Bollinger Band (20, 2)
115.33
Lower Bollinger Band (20, 2)
86.48
Previous Upper Bollinger Band (20, 2)
114.77
Previous Lower Bollinger Band (20, 2)
88.77
Income Statement Financials
Quarterly Revenue (MRQ)
Quarterly Net Income (MRQ)
-36,200,000
Previous Quarterly Revenue (QoQ)
Previous Quarterly Revenue (YoY)
Previous Quarterly Net Income (QoQ)
-69,005,000
Previous Quarterly Net Income (YoY)
-36,717,000
Revenue (MRY)
Net Income (MRY)
-155,203,000
Previous Annual Revenue
Previous Net Income
-208,018,000
Cost of Goods Sold (MRY)
Gross Profit (MRY)
Operating Expenses (MRY)
209,562,000
Operating Income (MRY)
-209,562,000
Non-Operating Income/Expense (MRY)
54,344,000
Pre-Tax Income (MRY)
-155,218,000
Normalized Pre-Tax Income (MRY)
-155,218,000
Income after Taxes (MRY)
-155,203,000
Income from Continuous Operations (MRY)
-155,203,000
Consolidated Net Income/Loss (MRY)
-155,203,000
Normalized Income after Taxes (MRY)
-155,203,000
EBIT (MRY)
-209,562,000
EBITDA (MRY)
-209,562,000
Balance Sheet Financials
Current Assets (MRQ)
1,173,003,000
Property, Plant, and Equipment (MRQ)
Long-Term Assets (MRQ)
Total Assets (MRQ)
1,173,003,000
Current Liabilities (MRQ)
63,302,000
Long-Term Debt (MRQ)
Long-Term Liabilities (MRQ)
8,560,000
Total Liabilities (MRQ)
71,862,000
Common Equity (MRQ)
954,716,200
Tangible Shareholders Equity (MRQ)
1,101,141,000
Shareholders Equity (MRQ)
1,101,141,000
Common Shares Outstanding (MRQ)
88,064,000
Cash Flow Statement Financials
Cash Flow from Operating Activities (MRY)
-169,252,000
Cash Flow from Investing Activities (MRY)
-143,475,000
Cash Flow from Financial Activities (MRY)
309,025,000
Beginning Cash (MRY)
89,423,000
End Cash (MRY)
85,721,000
Increase/Decrease in Cash (MRY)
-3,702,000
Fundamental Ratios
PE Ratio (Current Year Earnings Estimate)
PE Ratio (Trailing 12 Months)
PEG Ratio (Long Term Growth Estimate)
Price to Sales Ratio (Trailing 12 Months)
Price to Book Ratio (Most Recent Quarterly Book Value per Share)
8.15
Price to Cash Ratio (Most Recent Annual Cash Flow per Share)
Pre-Tax Margin (Trailing 12 Months)
Net Margin (Trailing 12 Months)
Return on Equity (Trailing 12 Months)
-30.74
Return on Assets (Trailing 12 Months)
-22.23
Current Ratio (Most Recent Fiscal Quarter)
18.53
Quick Ratio (Most Recent Fiscal Quarter)
18.53
Debt to Common Equity (Most Recent Fiscal Quarter)
0.00
Inventory Turnover (Trailing 12 Months)
Book Value per Share (Most Recent Fiscal Quarter)
10.86
Earnings
Fiscal Period End, Next Quarterly Earnings Report
2026-09-30
Quarterly Earnings per Share Estimate
-0.80
Next Expected Quarterly Earnings Report Date
2026-11-03
Days Until Next Expected Quarterly Earnings Report
61
Fiscal Period End, Last Quarterly Earnings Report
2026-06-30
Last Quarterly Earnings per Share Estimate
-0.71
Last Quarterly Earnings per Share
-0.36
Last Quarterly Earnings Report Date
2026-08-04
Days Since Last Quarterly Earnings Report
30
Earnings per Share (Most Recent Fiscal Year)
-1.98
Diluted Earnings per Share (Trailing 12 Months)
-1.95
Dividends
Last Dividend Date
Last Dividend Amount
Days Since Last Dividend
Annual Dividend (Based on Last Quarter)
0.00
Dividend Yield (Based on Last Quarter)
0.00
Percent Growth in Revenue/Net Income
Percent Growth in Quarterly Revenue (QoQ)
Percent Growth in Quarterly Revenue (YoY)
Percent Growth in Annual Revenue
Percent Growth in Quarterly Net Income (QoQ)
47.54
Percent Growth in Quarterly Net Income (YoY)
1.41
Percent Growth in Annual Net Income
25.39
New High/Low in Revenue/Net Income
New 5-Year High Annual Revenue
False
New 5-Year Low Annual Revenue
False
New 5-Year High Quarterly Revenue (QoQ)
False
New 5-Year Low Quarterly Revenue (QoQ)
False
New 5-Year High Quarterly Revenue (YoY)
False
New 5-Year Low Quarterly Revenue (YoY)
False
New 5-Year High Annual Net Income
False
New 5-Year Low Annual Net Income
False
New 5-Year High Quarterly Net Income (QoQ)
False
New 5-Year Low Quarterly Net Income (QoQ)
False
New 5-Year High Quarterly Net Income (YoY)
False
New 5-Year Low Quarterly Net Income (YoY)
False
Consecutive Quarters/Years of Increasing/Decreasing Revenue/Net Income
Consecutive Quarters of Increasing Revenue (QoQ)
2
Consecutive Quarters of Decreasing Revenue (QoQ)
0
Consecutive Quarters of Increasing Revenue (YoY)
0
Consecutive Quarters of Decreasing Revenue (YoY)
1
Consecutive Years of Increasing Revenue
0
Consecutive Years of Decreasing Revenue
3
Consecutive Quarters of Increasing Net Income (QoQ)
1
Consecutive Quarters of Decreasing Net Income (QoQ)
0
Consecutive Quarters of Increasing Net Income (YoY)
1
Consecutive Quarters of Decreasing Net Income (YoY)
0
Consecutive Years of Increasing Net Income
2
Consecutive Years of Decreasing Net Income
0
Splits
Last Split Date (if within past year)
Last Split Ratio (if within past year)
Days Since Last Split (if within past year)
Volatility Metrics
Historical Volatility (Close-to-Close) (10-Day)
0.7472
Historical Volatility (Close-to-Close) (20-Day)
0.6303
Historical Volatility (Close-to-Close) (30-Day)
0.6346
Historical Volatility (Close-to-Close) (60-Day)
0.6276
Historical Volatility (Close-to-Close) (90-Day)
0.6935
Historical Volatility (Close-to-Close) (120-Day)
0.6638
Historical Volatility (Close-to-Close) (150-Day)
0.7169
Historical Volatility (Close-to-Close) (180-Day)
0.7116
Historical Volatility (Parkinson) (10-Day)
0.4545
Historical Volatility (Parkinson) (20-Day)
0.4882
Historical Volatility (Parkinson) (30-Day)
0.4838
Historical Volatility (Parkinson) (60-Day)
0.5581
Historical Volatility (Parkinson) (90-Day)
0.5637
Historical Volatility (Parkinson) (120-Day)
0.5565
Historical Volatility (Parkinson) (150-Day)
0.6052
Historical Volatility (Parkinson) (180-Day)
0.6003
Implied Volatility (Calls) (10-Day)
0.7003
Implied Volatility (Calls) (20-Day)
0.7114
Implied Volatility (Calls) (30-Day)
0.7391
Implied Volatility (Calls) (60-Day)
0.7746
Implied Volatility (Calls) (90-Day)
0.7633
Implied Volatility (Calls) (120-Day)
0.7464
Implied Volatility (Calls) (150-Day)
0.7374
Implied Volatility (Calls) (180-Day)
0.7301
Implied Volatility (Puts) (10-Day)
0.6954
Implied Volatility (Puts) (20-Day)
0.7085
Implied Volatility (Puts) (30-Day)
0.7414
Implied Volatility (Puts) (60-Day)
0.7885
Implied Volatility (Puts) (90-Day)
0.7785
Implied Volatility (Puts) (120-Day)
0.7556
Implied Volatility (Puts) (150-Day)
0.7461
Implied Volatility (Puts) (180-Day)
0.7433
Implied Volatility (Mean) (10-Day)
0.6978
Implied Volatility (Mean) (20-Day)
0.7099
Implied Volatility (Mean) (30-Day)
0.7403
Implied Volatility (Mean) (60-Day)
0.7815
Implied Volatility (Mean) (90-Day)
0.7709
Implied Volatility (Mean) (120-Day)
0.7510
Implied Volatility (Mean) (150-Day)
0.7417
Implied Volatility (Mean) (180-Day)
0.7367
Put-Call Implied Volatility Ratio (10-Day)
0.9930
Put-Call Implied Volatility Ratio (20-Day)
0.9960
Put-Call Implied Volatility Ratio (30-Day)
1.0031
Put-Call Implied Volatility Ratio (60-Day)
1.0179
Put-Call Implied Volatility Ratio (90-Day)
1.0198
Put-Call Implied Volatility Ratio (120-Day)
1.0124
Put-Call Implied Volatility Ratio (150-Day)
1.0118
Put-Call Implied Volatility Ratio (180-Day)
1.0182
Implied Volatility Skew (10-Day)
-0.1364
Implied Volatility Skew (20-Day)
-0.1184
Implied Volatility Skew (30-Day)
-0.0734
Implied Volatility Skew (60-Day)
-0.0059
Implied Volatility Skew (90-Day)
-0.0040
Implied Volatility Skew (120-Day)
-0.0086
Implied Volatility Skew (150-Day)
-0.0063
Implied Volatility Skew (180-Day)
-0.0051
Option Statistics
Put-Call Ratio (Volume) (10-Day)
35.0000
Put-Call Ratio (Volume) (20-Day)
42.1429
Put-Call Ratio (Volume) (30-Day)
60.0000
Put-Call Ratio (Volume) (60-Day)
46.1429
Put-Call Ratio (Volume) (90-Day)
0.0000
Put-Call Ratio (Volume) (120-Day)
Put-Call Ratio (Volume) (150-Day)
Put-Call Ratio (Volume) (180-Day)
Put-Call Ratio (Open Interest) (10-Day)
4.4324
Put-Call Ratio (Open Interest) (20-Day)
5.4420
Put-Call Ratio (Open Interest) (30-Day)
7.9662
Put-Call Ratio (Open Interest) (60-Day)
6.4308
Put-Call Ratio (Open Interest) (90-Day)
0.4239
Put-Call Ratio (Open Interest) (120-Day)
0.2819
Put-Call Ratio (Open Interest) (150-Day)
0.1432
Put-Call Ratio (Open Interest) (180-Day)
0.2393
Percentiles Within Industry of Price Performance
Percentile Within Industry, Percent Change in Price, Past 52 Weeks
97.20
Percentile Within Industry, Percent Change in Price, Past 26 Weeks
94.40
Percentile Within Industry, Percent Change in Price, Past 13 Weeks
63.59
Percentile Within Industry, Percent Change in Price, Past 4 Weeks
12.52
Percentile Within Industry, Percent Change in Price, Past 2 Weeks
4.61
Percentile Within Industry, Percent Change in Price, Past Week
21.09
Percentile Within Industry, Percent Change in Price, 1 Day
15.32
Percentiles Within Industry of Revenue/Net Income Growth
Percentile Within Industry, Percent Growth in Quarterly Revenue (QoQ)
Percentile Within Industry, Percent Growth in Quarterly Revenue (YoY)
Percentile Within Industry, Percent Growth in Annual Revenue
Percentile Within Industry, Percent Growth in Quarterly Net Income (QoQ)
84.84
Percentile Within Industry, Percent Growth in Quarterly Net Income (YoY)
58.30
Percentile Within Industry, Percent Growth in Annual Net Income
73.30
Percentiles Within Industry of Fundamental Ratios and Percentages
Percentile Within Industry, PE Ratio (Current Year Earnings Estimate)
Percentile Within Industry, PE Ratio (Trailing 12 Months)
Percentile Within Industry, PEG Ratio (Long Term Growth Estimate)
Percentile Within Industry, Price to Sales Ratio (Trailing 12 Months)
Percentile Within Industry, Price to Book Ratio (Most Recent Quarterly Book Value per Share)
83.56
Percentile Within Industry, Price to Cash Ratio (Most Recent Annual Cash Flow per Share)
Percentile Within Industry, Pre-Tax Margin (Trailing 12 Months)
Percentile Within Industry, Net Margin (Trailing 12 Months)
Percentile Within Industry, Return on Equity (Trailing 12 Months)
77.43
Percentile Within Industry, Return on Assets (Trailing 12 Months)
77.86
Percentile Within Industry, Current Ratio (Most Recent Fiscal Quarter)
89.49
Percentile Within Industry, Quick Ratio (Most Recent Fiscal Quarter)
89.25
Percentile Within Industry, Debt to Common Equity (Most Recent Fiscal Quarter)
71.56
Percentile Within Industry, Inventory Turnover (Trailing 12 Months)
Percentile Within Industry, Dividend Yield (Based on Last Quarter)
99.18
Percentile Within Industry, Percentage Held By Insiders (Latest Annual Proxy Report)
72.18
Percentile Within Industry, Percentage Held By Institutions (Latest 13F Reports)
77.65
Percentiles Within Sector of Price Performance
Percentile Within Sector, Percent Change in Price, Past 52 Weeks
98.38
Percentile Within Sector, Percent Change in Price, Past 26 Weeks
95.15
Percentile Within Sector, Percent Change in Price, Past 13 Weeks
64.03
Percentile Within Sector, Percent Change in Price, Past 4 Weeks
13.89
Percentile Within Sector, Percent Change in Price, Past 2 Weeks
4.76
Percentile Within Sector, Percent Change in Price, Past Week
19.22
Percentile Within Sector, Percent Change in Price, 1 Day
15.13
Percentiles Within Sector of Revenue/Net Income Growth
Percentile Within Sector, Percent Growth in Quarterly Revenue (QoQ)
Percentile Within Sector, Percent Growth in Quarterly Revenue (YoY)
Percentile Within Sector, Percent Growth in Annual Revenue
Percentile Within Sector, Percent Growth in Quarterly Net Income (QoQ)
79.40
Percentile Within Sector, Percent Growth in Quarterly Net Income (YoY)
53.08
Percentile Within Sector, Percent Growth in Annual Net Income
68.58
Percentiles Within Sector of Fundamental Ratios and Percentages
Percentile Within Sector, PE Ratio (Current Year Earnings Estimate)
Percentile Within Sector, PE Ratio (Trailing 12 Months)
Percentile Within Sector, PEG Ratio (Long Term Growth Estimate)
Percentile Within Sector, Price to Sales Ratio (Trailing 12 Months)
Percentile Within Sector, Price to Book Ratio (Most Recent Quarterly Book Value per Share)
83.94
Percentile Within Sector, Price to Cash Ratio (Most Recent Annual Cash Flow per Share)
Percentile Within Sector, Pre-Tax Margin (Trailing 12 Months)
Percentile Within Sector, Net Margin (Trailing 12 Months)
Percentile Within Sector, Return on Equity (Trailing 12 Months)
58.26
Percentile Within Sector, Return on Assets (Trailing 12 Months)
56.52
Percentile Within Sector, Current Ratio (Most Recent Fiscal Quarter)
93.10
Percentile Within Sector, Quick Ratio (Most Recent Fiscal Quarter)
93.16
Percentile Within Sector, Debt to Common Equity (Most Recent Fiscal Quarter)
56.47
Percentile Within Sector, Inventory Turnover (Trailing 12 Months)
Percentile Within Sector, Dividend Yield (Based on Last Quarter)
93.05
Percentile Within Sector, Percentage Held By Insiders (Latest Annual Proxy Report)
73.33
Percentile Within Sector, Percentage Held By Institutions (Latest 13F Reports)
72.71
Percentiles Within Market of Price Performance
Percentile Within Market, Percent Change in Price, Past 52 Weeks
99.72
Percentile Within Market, Percent Change in Price, Past 26 Weeks
98.59
Percentile Within Market, Percent Change in Price, Past 13 Weeks
88.12
Percentile Within Market, Percent Change in Price, Past 4 Weeks
8.27
Percentile Within Market, Percent Change in Price, Past 2 Weeks
2.92
Percentile Within Market, Percent Change in Price, Past Week
10.28
Percentile Within Market, Percent Change in Price, 1 Day
8.84
Percentiles Within Market of Revenue/Net Income Growth
Percentile Within Market, Percent Growth in Quarterly Revenue (QoQ)
Percentile Within Market, Percent Growth in Quarterly Revenue (YoY)
Percentile Within Market, Percent Growth in Annual Revenue
Percentile Within Market, Percent Growth in Quarterly Net Income (QoQ)
68.97
Percentile Within Market, Percent Growth in Quarterly Net Income (YoY)
42.07
Percentile Within Market, Percent Growth in Annual Net Income
65.18
Percentiles Within Market of Fundamental Ratios and Percentages
Percentile Within Market, PE Ratio (Current Year Earnings Estimate)
Percentile Within Market, PE Ratio (Trailing 12 Months)
Percentile Within Market, PEG Ratio (Long Term Growth Estimate)
Percentile Within Market, Price to Sales Ratio (Trailing 12 Months)
Percentile Within Market, Price to Book Ratio (Most Recent Quarterly Book Value per Share)
89.19
Percentile Within Market, Price to Cash Ratio (Most Recent Annual Cash Flow per Share)
Percentile Within Market, Pre-Tax Margin (Trailing 12 Months)
Percentile Within Market, Net Margin (Trailing 12 Months)
Percentile Within Market, Return on Equity (Trailing 12 Months)
22.34
Percentile Within Market, Return on Assets (Trailing 12 Months)
19.28
Percentile Within Market, Current Ratio (Most Recent Fiscal Quarter)
96.14
Percentile Within Market, Quick Ratio (Most Recent Fiscal Quarter)
96.29
Percentile Within Market, Debt to Common Equity (Most Recent Fiscal Quarter)
32.85
Percentile Within Market, Inventory Turnover (Trailing 12 Months)
Percentile Within Market, Dividend Yield (Based on Last Quarter)
62.79
Percentile Within Market, Percentage Held By Insiders (Latest Annual Proxy Report)
72.42
Percentile Within Market, Percentage Held By Institutions (Latest 13F Reports)
70.41